The Development of diazepam as an anxiolytic Essay

The Development of diazepam as an anxiolytic - Essay Example Later, diazepam was marketed in 1963 by Hoffmann–La Roche under the trade name Valium. Thus two drugs emerged as the most successful commercially available drugs revolutionizing the science of anti-anxiolytic drugs. By the year 1970s they potentially replaced older drugs for sedative and hypnotic uses (Shorter, 2005). Diazepam belongs to benzodiazepine group. Diazepam acts on ascending reticular formation (responsible for wakefulness) in midbrain and on limbic system (responsible for thought). Muscle relaxation is produced by primary medullary site of action and ataxia is due to action on cerebellum (Tripathi, 2008; Rang & Dale, 2007; Brunton, 2005). Diazepam binds to benzodiazepine binding site on GABAA receptor Cl- channel complex. GABAA receptor is a pentameric structure (like a lily flower). It contains many sub-units and encloses Cl- channel. The opening of Cl- channel is modulated by GABA. Diazepam by binding to benzodiazepine binding site (ÃŽ ±/ÃŽ ³ subunit interface) facilitates GABA action (more amount of GABA will bind to GABAA receptor). It is not a GABA mimetic, it only facilitates GABA mediated Cl- channel opening. Opening of Cl- channel causes influx of Cl- ions and causes hyperpolarization. This decreases the firing rate of neurons. Therefore it possesses hypnotic action- induction of sleep- reticular activating system- depresses CNS- decreases the spread of epileptic discharge, therefore possesses anticonvulsant action (Tripathi, 2008; Rang & Dale, 2007; Brunton, 2005). The chloride channel is gated by the primary ligand GABA acting on GABAA receptor located on the ÃŽ ²- subunit. The benzodiazepine (BZD) receptor located on the interface of ÃŽ ± and ÃŽ ³ subunits modulates GABAA receptor in either direction (Tripathi, 2008). Oral absorption of Diazepam is good. Diazepam is widely distributed in body; absorption from intramuscular site of administration is

How Does Atticus Creates an Impact Essay Example for Free

How Does Atticus Creates an Impact Essay This was greatly influenced by their father, Atticus and the case of Tom Robinson in which Atticus was defending Tom. Atticus was a proud and dignified person in Maycomb. Everyone in Maycomb respects him and he also respects himself. When Atticus was given the case of Tom Robinson, because he always wants to do what he sees as being right, he has to take Tom’s case because he sees this as his duty. Although he knows this case was a lost one because of the racial society he lives in where a white person’s words always triumph over a black person’s words, he still tries his utmost best to defend Tom Robinson. I’ve got to live with myself† is how he explains his determination to Scout. If he didn’t defend Tom, he â€Å"couldn’t hold up his head in town. † Because his would have proved that he was as just as racial as the Maycomb folks. Atticus was â€Å"the deadest shot in Maycomb County† and he was nicknamed â€Å"One-Shot Finch† but he never boasted about his talent and he certainly disapproves of Scout boasting on his behalf. Despite his many talents, Atticus was a modest man. He never looks down on others despite his achievements, career and education status. He respected people of colour. A perfect example of this was that he lets Calpurnia run his entire household. Atticus was constantly criticized and attacked by members of the community of Maycomb before and during the trial but he does not take advantage of his social standing to retaliate or rebuke them. He remains clam when he was provoked directly. When Bob Ewell spits in Atticus’ face and Bob Ewell said â€Å"Too proud to fight? † Atticus simply replied â€Å"No, too old. He just wipes his face after Bob Ewell was finished swearing at him and walked off calmly. This showed that Atticus has more character than Bob Ewell. After that scenario, Atticus thought that Bob Ewell let all his anger out but this was one of Atticus’ few mistakes of judgement of character where this shows that he was not perfect, he was human. Atticus treats his children as intelligent individuals, where if they ask him a question, he answers in a clear matter – of –fact wa y and he answers his questions directly. A good example of this was where Scout does not want to go to school because she cannot read in school; he clearly explains what it actually is. â€Å"Do you know what a compromise is? † he asked. â€Å"No, an agreement reached by mutual concessions. It works this way,† he said. â€Å"If you’ll concede the necessity of going to school, we’ll go on reading every night just as we always have. † That compromise also shows that Atticus has good parenting skills. Atticus was a very fair person, so in instances of an argument, he listens to both sides of the story and then concludes a verdict. This was told to the reader when Scout was explaining to Uncle Jack why he wasn’t fair in dealing with the situation with Scout and Francis â€Å"Well, in the first place you never stopped to gimme a chance to tell you my side of it—you just lit right into me. When Jem an’ I fuss Atticus doesn’t ever just listen to Jem’s side of it, he hears mine too† Atticus has never beaten his children but he firmly scolds them in certain situations. For example when he makes Jem go and read for Mrs Dubose â€Å"Atticus, she wants me to read to her. Yes sir. She wants me to come every afternoon after school and Saturdays and read to her out loud for two hours. Atticus, do I have to? † â€Å"Certainly,† said Atticus. In conclusion, we all, as readers, see that Atticus has an impact in some way on every person living in Maycomb county either directly or indirectly. Also, we see that Atticus tries his best to grow up his children in the best way possible and answer all their questions when asked instead of just delving into another topic.

The Definition And Concept Of Spatial Integration Cultural Studies Essay

The Definition And Concept Of Spatial Integration Cultural Studies Essay The definition and concept of Spatial Integration in historic cities or towns is not accurately defined as it has been seen as an essential component of the present integration in the cities of towns. According  [1]  to European Spatial Development Programme (ESDP) under the Noordwijk project, Spatial integration expresses the opportunities for and level of (economic, cultural) interaction within and between areas and may reflect the willingness to co-operate. It also indicates, for example, levels of connectivity between transport systems of different geographical scales. Spatial integration is positively influenced by the presence of efficient administrative bodies, physical and functional complementarity between areas and the absence of cultural and political controversies. In itself, the term interaction can seem at least as global as the one of integration. However, this term, often coupled with the spatial or territorial qualifier is often used in scientific literature, in particular by geographers. In a wide sense, the concept of spatial interaction can be related to any kind of relationship between places (connexity, similarity, flows, and proximity) and one could assimilate the analysis of spatial interaction to spatial analysis in itself, or even to geography. In the practice of (mainly geographical) research, spatial interaction often takes a more limited and technical meaning and may refer to a phenomenon described as decreasing of the intensity of flows with distance. Different spatial interaction models have been built in order to give account of this phenomenon, many of them relying on the general gravity model, based on distance and on relative weights of the considered entities. Taking into account the ESDP definition, its global approach as well as the history of the criterion, it seems that interaction must be understood here as a rather comprehensive concept, that cannot be directly limited to some domains of relationships, nor even to spatial interaction as it is generally understood. For example the definition mentions interaction between areas rather than spatial interaction, which could indicate that distance is not necessarily seen as central (maybe because the concept of distance is more specific of another criterion, Geogr aphic position) The ESDP definition, through its reference to willingness to co-operate and to absence of cultural and political controversies, also indicates that the social and human aspects play an important role in an open minded approach of the concept of spatial interaction. Besides its various interpretations, use of the term interaction in the definition of the Noordwijk draft of ESDP can also be seen as conveying some implicit ideas through its etymology. Spatial integration and (spatial) cohesion:- There is often reference to the terms which are or their meaning is related or closed to the integration in the European documents. In the Article B under title I of Treaty of European Union, the most often term under the aims and objectives, is the economic and social cohesion. There is no specific definition of cohesion (Economic and social) in the Treaty, but there is reference is to reduce the disparities between the levels of development of the various regions and the backwardness of the least favoured regions, including rural areas. The analysis of the first report on social and economic cohesion describes the situation of the European regions in the same perspective of assessment of inequalities and of their trends. In those terms, cohesion seems closely related to the idea of homogeneity and Spatial (or territorial) cohesion is relatively less mentioned compared to social and economic cohesion. Spatial integration and co-operation:- The Noordwijk project of ESDP introduces in its definition the concept of willingness to co-operate, as a basis for spatial integration. This adds an important dynamic element to understanding of territorial (or spatial) integration. Co-operation is often associated to integration, although there are some fundamental differences between the two concepts. A priori, the concept of spatial interaction, which is at the core of the definition of spatial integration, has no positive or negative sense. Spatial interaction generally relies on human motivation (even if natural phenomena such as floods may cause spatial interaction), but these motivations might not be shared by all actors nor lead to win-win situations. In contrast, absence of co-operation may result either in a limited level of spatial interaction, as relationships will not be supported by all actors, or in unbalanced relationships solely ruled by the law of the strongest. Lack of co-operation can be observed in practice in some cases where actual relations are less than one would expect in view of shared interests, physical possibilities available, or presence of spatial systems to manage (e.g. river basins). But absence of co-operation may also exist where integration (in terms of interactions) is strong, and in those cases it may have harmful effects for some of the partners. Although the ESDP mentions the willingness to co-operate, it must be said that co operation does not always rely on willingness but also on need to co-operate. This allows us to distinguish between situations that require co-operation (even if the partners are somewhat reluctant) and situations where spatial integration is actually weak but the willingness to co-operate exists. In the second case, certain material organisational changes may lead to an increase in the significance of relations between areas. Attempting to translate the concept of spatial co-operation into indicators is recognised as being a very difficult task, as co-operation mainly relies on a state of mind and on organisational patterns that do not necessarily imply easily measurable phenomena. Networks of places:- For many authors, it is useful to reflect further on how places are linked, in order that integration might occur. Places are no longer considered as simple geographical constructs; rather they are defined through social analysis (for a review, see Amin and Graham, 1998). These stress that places are articulated moments in networks of social relations and understandings rather than areas with boundaries around (Massey, 1993; 66). In this configuration socially-constructed places are noncontiguous, diverse, dynamic and superimposed. As well as being bound to place-based relations, cultural, social, economic, political and environmental links and relations can be stretched across space (Graham and Healey, 1999 (forthcoming)). This partially reflects a more sophisticated analysis of how networks of cities and towns interact, an area that Theme 2 explores further. As Dematteis notes we have witnessed the passage from a functional organisation in which the centres are graded with a multi-level hierarchy (as in the models of Christaller and Là ¶sch) to interconnected networks organised on the basis of the corresponding complementarities of the nodes and the synergies produced (Dematteis, 1994). It also reflects an understanding that it is not places which interact but the people and organisations (actors) which inhabit that space. Geoff Mulgan (1997) labels the current era one of Connexity. This reflects the ESDPs definition of spatial integration as: Opportunities for and level of interaction within and between areas. In Mulgans view cultures, economies, social worlds, politics and environments all become driven by logics of increasingly intense interconnections and flows, over larger and larger geographical scales. A growing range of economic, social, and cultural interactions which are both in place and out of place (Adams, 1996; 279) are being supported by modern communications technologies (Graham and Healey, ibid.). Of course, it is possible that connections may only occur between specific sections of society. We may therefore witness different social geographies of spatial integration. The Noordwijk project of ESDP suggests that measures of spatial integration will include levels of linkage between transport systems at different geographical scales. However, a fuller interpretation of the conception offered above implies that spatial integration is wider than simply transport linkages but includes all transactions (or flows) between areas. To Mulgan, the growing importance of network-based connections means that economies are increasingly driven by the logical or virtual regularities of electronic communication, a new geography of nodes and hubs, processing and control centres. The nineteenth centurys physical infrastructures of railways, canals and roads are now overshadowed by the networks of computers, cables and radio links that govern where things go, how they are paid for, and who has access to what. The physical manifestation of power, walls, boundaries, highways and cities, are overlaid with a virtual world of information hubs, databases and networks (Mulgan, 1991; 3). India: According  [3]  to Jordar, Souro D., Spatial integration is the combination of all the activities like economic, social and physical which can be achieved by the modern spatial planning tools and techniques, different and dual modes for the participation towards development in the cities. There are very few cities in India which have undergone planned development by using the modern spatial planning tools and techniques towards spatial integration. The author signifies the role of resources like land and infrastructure in the spatial integration of cities. Moreover, the role of modes like public and private sectors, public/private sector for the development of spatial integration, is also most important for spatial development. Brazil: According  [4]  to Edja Bezerra Faria and Valerio Augusto in their paper, Spatial Integration/Configuration is a set of independent relations in which each is determined by its relation to others and the fundamental correlate is of the spatial integration/configuration is movement . But according  [5]  to Hillier, (1996, 35/152), The structure of the grid considered purely as a spatial integration/configuration, is itself the most powerful determinant of urban movement, both pedestrian and vehicular. Because this relation is fundamental and lawful, it has already been a powerful force in shaping our historically evolved cities, by its effect on land use patterns, building densities and part-whole structure of the city. South America: According  [6]  to Poul Ove Pedersen and Walter Stà ¶hr Spatial development and Economic Integration is associated with spatial distribution of physical geographical patterns, transport networks, economic activities, natural resources different policies etc and change is these factors can change the spatial integration pattern in the areas/city or in the region. South Africa: Within the constitution, for the basis of new development and local government system, white paper was introduced which highlights and committed to cover all the sectors to meet the demands of the society. According  [7]  to it, Spatial integration is a strategy for doing away with the expensive and exclusionary land-use patterns of apartheid. It seeks to enhance the efficiency of the city by placing residential development closer to job opportunities, and reduce the costs of development by exploiting surplus bulk infrastructural capacity. Spatial integration also has a social dimension and can increase the access of low-income residents to facilities and opportunities in the city. For the Integration of cities, towns and rural areas which has different spatial dimensions like social, an economic etc, the objective is to create more efficient and equitable cities, towns and rural areas. In Contrast to many literatures, Hilliers establishment of a theory of space as configuration and series of related methodologies, called space syntax, (Hillier Hanson, 1984; Hillier, 1996) that spreads a new light on the spatial formation of area structure. Hillier (1987, 1989) first suggested that optimizing correlations between spatial configuration measured by spatial integration and movement rates and the growth of settlements changes the pattern of Integration. The concept of spatial integration was also identified in the European Spatial Development Programme (ESDP) throughout the various versions. The First document which was on spatial planning issues, when it appeared first time in 1994 and it was centred on the specific aspect of cross-border relationships but slowly it came out with wider vision which was summarised later in the first official project of ESDP. After the evolution of Noordwijk, 1997, the next version of ESDP was produced in Glasgow in 1998 which came out with removal of few terms (economic, cultural) while it maintained the definition. Later on, the final and official version was adopted in Postdam, 1999 in which no indications on the definition of spatial integration or the concept of spatial integration. The CEMAT also gave same kind of Guidelines for Sustainable Spatial Planning to maintain spatial balance. It was also asked to produce synthetic indexes which should be able to take into account the seven dimensions of spatial differentiation in a global approach. These criteria, it is argued, provide a starting point for recognising and assessing the spatial dimension of the ESDP and, in combination, have a particular value for the purpose of spatial analysis. As it was recognised, spatial integration is, perhaps, one of the criteria which is most directly related to the concept of spatial planning itself. Consequently, and by virtue of its comprehensive nature, it may often overlap the fields of interest of the other criteria. From the start criterion has an overlay with the criteria Geographical position (1.1) but also with all the other criteria of spatial differentiation and probably with all the other parts of the call for proposals. In other words, the question of spatial integration is present everywhere in the SPESP and it is well known that what is everywhere is also nowhere. For example, there is a potential overlap between spatial integration and geographical position on the questions of distances and of transport and communication infrastructures. Some less obvious overlaps may occur with social integration (about integration factors such as language, culture, political sensitivity), with economic strength (economic functions generating relationships), with land use pressure (impact on migration moves through effects on land prices) or with natural and cultural assets (common resources that can account for spatial relationships). Links exist also with work on the urban rural relationships typology and urban rural partnerships considered under theme 2. All this indicates that one of the first tasks related to the work on this study strand is a deepening of the concepts, taking into account not only the concept of spatial integration itself, but also some other related concepts that may help to delineate the field of the study. The previous points all go to show how interrelated the concept of spatial integration is with concepts such as economic and social integration. Far from serving to narrow its field of application, the body of literature concerned with spatial integration is in fact serving to widen its influence. This raises the question of identifying the specific nature of spatial integration, and reminds of another similar question, that is identification of the specific nature of spatial planning / spatial development. In both cases, the multi-facetted nature generates a difficulty to focus on specific issues, notably because isolating the spatial dimension of a reality is a rather abstract exercise whose practical purpose is not always obvious to perceive.

A Patriarchic Society in Aphra Behns The Rover Essay -- Aphra Behn Ro

A Patriarchic Society in Aphra Behn's The Rover In her play The Rover, Aphra Behn uses the treatment of women to suggest the presence of a strong patriarchic society and what harm can become of it. The main female character Florinda is manipulated, used, and treated horribly by men in instances of near-rape, battering and beating, and foul language among other things. Behn also uses Willmore, one of the main male characters, and his attitude towards women to prove her point. By doing this, Behn is suggesting patriarchy is dangerous for women, and their lack of fighting against it presupposes what can happen to women over time if this strong patriarchic society is allowed to flourish. In act three, Florinda is almost raped by a drunken Willmore. He doesn’t know who she is, he thinks she’s just, â€Å"A female! By this light, a woman! I’m a dog if it be not a very wench† (III.v.16 –17). This shows that he only sees her as a sex object. He then tries to take advantage of her. As she puts up a struggle, he says, â€Å"Come, come, take it or I’ll put it up again†¦Why, how now, mistress, are you so high i’th’ mouth a pistole won’t down with you? ...Come, no struggling to be gone†¦I’m for ye† (III.v.67 – 72), trying to force her into submission. In another instance in act four, the same thing nearly happens again to Florinda when she ventures into Blunt’s house. Blunt has been tricked by another woman and decides to take his revenge out on that woman by sleeping with Florinda. He gets very physical with her and Florinda protests with, â€Å"Dare you be s o cruel?† (IV.v.51). Blunt replies with this heartless speech: â€Å"Cruel? ...as a galley slave, or a Spanish whore†¦I will kiss and beat thee all over, kiss and see thee all over; ... ...the patriarchic society, Florinda’s father and brother won’t allow them to be married. She was treated as a prize awarded to the most eligible candidate. Here, Behn is showing how damaging the patriarchic tradition of arranged marriages can be to those involved. Even though they ended up together, they had to fight a battle to do so. By ending the play this way, Behn is saying people who love each other shouldn’t have to fight to be together, thereby proving this patriarchic practice unfair. By placing an emphasis on the man who uses women as sex objects by titling her play after him; by having almost all the female characters in the play treated horribly, used, and manipulated; and having the female characters barely putting up a fight, Aphra Behn suggests the heavily patriarchic society that exists is too extensive and is dangerous for the women in it.

Diversity in the United States Essay

Diversity in the United States Introduction   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Diversity is the concept of acceptance and respect upon every individual in relations to sexual category, ethnic and sexual coordination, and stage of development, bodily abilities and political beliefs. In United States there is synthesis of world’s abundant and varied religions, cultures and ethnic groups since it is a home to everybody and there is no group which can call itself the most American than the other. However, the merging of cultures here is so irreplaceable and so outstanding that citizens can be just as pleased and proud of their main cultural legacy as they are to be an American after all. The diversity in United States assemblage takes a moral look at what it means to be an American and scrutinizes the rich legacies that encompasses the entire nation. Any culture provides its specific and incomparable contribution to the current understanding in America and to the world generally. The issue of diversity in America not only provides a multitude of friendly portraits of heritage and culture, but records the fights of nationalities to incorporate into the sentimental society of America, and highlights the power and honesty of several cultural influential and socialites (Naylor, 1999, Naylor, 1997).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   According to the current state of immigration in United States, diversity has however reached nearly every state in America. William Ferry, a demographer has stated that â€Å"This is just a strange explosion of diversity all across the United States† and thinks that diversity and immigration are going hand in hand. Due to the high of immigration, the current statistics indicate that Education ranks increased in every state from 2000 to 2010. Generally, the part of adults with 25 years and older with at least a high school diploma or certificate raised from 80 percent to 90 percent. Those adults with at least a bachelor’s degree from any university or college raised from 40 percent to 55 percent. This change could even rise higher in the coming years as far as there are available jobs and the growth of economy still continue growing in order to hold the population. Furthermore, there are all categories of construction, food p rocessing, every kind of service jobs, the full scale, where primary agriculture is practiced (Naylor, 1997)   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Immigrants have also enriched American communities by bringing characteristics of their instinctive cultures with them. However, many of the black Americans now celebrate both Christmas and other festivals drawn from African rituals. Hispanic Americans enjoy their backgrounds with street fairgrounds and other parties or events. There are many ethnic restaurants that proliferate in many American cities. For example, President John Kennedy, the grandson of Irish immigrants, commissioned up this intermingling of the old and the new when he titled America as a society of immigrants, which could hold any person irrespective of their culture, race, religion or political ideologies and everyone would began life fresh, on an equal basis. Therefore, this is the secret of United State as a nation of people with the fresh retention of old backgrounds who venture to walk around with new borderlines (Lind, 2010).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   However, apart from the benefits which have been brought by the immigrants in the United States, challenges have been there more so to the government on how to counter the growing population. Services in all fields need to be increased and improved that is in organizational centers, health centers and educational centers because among the immigrants there are disabled people or people with special needs and they all expect assistance from the government. The issue of ethnicity is still there among various groups of people and this has led to gender difference and reduced sexual orientation. The uniformity that is beyond our internal extents there is outward effects of life practices, plus the choices we decide in our lives also affect our chances, circumstances, and elevations and since these controls, outward extents of religion, maternal prominence, and presence may influence others to create conventions about the immigrants (Naylor 1999 ).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Therefore, diversity need to be fostered in all terms of climate of acceptance and cultural pluralism in the United States in the following ways. First, Asian, Hispanic, black, and American Indian kids require the same basic skills that we have low priorities that white children require. This is a recognizable point, but it is most forgotten idea when the subject of multiethnic education is raised. Second, they need a broad considerate of our form of government and its organizations because we live in a country in which we enjoy countless freedom, but we also live in a country in which people are extremely unconcerned. Third, we must teach our children the history of this United States and there are many sources where we can get that history. Finally, all American kids need a well understanding of the world in which we live, and this includes something of the history of other nations. They need a foundation in geography, which, if shown we ll, will also teach them why nations advanced as they did. Rivers, terrain and climate are all important to the improvement of culture and should be understood well (Naylor, 1997).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The ways in which media perpetuate stereotyping and prejudice are relatively few. Erratically, there are studies within fields of journalism and mass communication that concentrate on stereotype and prejudice decline. One of the way is applying an audience-based tactic that openly teaches audiences how to be critical media consume while the other method is using message based method which enables the participants with all stereotypical news narratives that explain the existing cultural practices about various racial groups. The results of these two media-based methods on the accessibility of unfriendly and compassionate racial typecasts are considered to be having a great change. Finally every individual need to construct up prejudice like in other states such as Germany, china and Japan to improve our entrepreneurship. This may be called Ideology but we have to become one, not diverse and unlike (Lester, 2011, Lind, 2010). References Lester, P. M. (2011). Images That Injure: Pictorial Stereotypes in the Media, Third Edition. Santa Barbara: ABC-CLIO. Lind, R. A. (2010). Race/gender/media: Considering diversity, across audiences, content, and producers. Boston: Allyn & Bacon. Naylor, L. L. (1999). Problems and issues of diversity in the United States. Westport, Conn. [u.a.: Bergin & Garvey. Naylor, L. L. (1997). Cultural diversity in the United States. Westport, Conn. [u.a.: Bergin & Garvey. Source document

The Ottoman Sultans Were Not Very Turkish

The Ottoman Sultans Were Not Very Turkish The Ottoman Empire ruled over what is now Turkey and a large portion of the eastern Mediterranean world from 1299 until 1923. The rulers, or sultans, of the Ottoman Empire had their paternal roots in Oghuz Turks of Central Asia, also known as the Turkmen.   The History of Concubine Mothers However, most of the sultans mothers were concubines from the royal harem - and most of the concubines were from non-Turkic, usually non-Muslim parts of the empire. Much like the boys in the Janissary corps, most concubines in the Ottoman Empire were technically members of the slave class. The Quran forbids the enslavement of fellow Muslims, so the concubines were from Christian or Jewish families in Greece or the Caucasus, or were prisoners of war from further afield. Some residents of the harem were official wives, as well, who might be noblewomen from Christian nations, married to the sultan as part of diplomatic negotiations. Although many of the mothers were slaves, they could amass incredible political power if one of their sons became the sultan. As valide sultan, or Mother Sultan, a concubine often served as de facto ruler in the name of her young or incompetent son. Ottoman Royal Genealogy The Ottoman royal genealogy begins with Osman I (r. 1299 - 1326), both of whose parents were Turks. The next sultan likewise was 100% Turkic, but beginning with the third sultan, Murad I, the sultans mothers (or valide sultan) were not of Central Asian origins. Murad I (r. 1362 - 1389) was 50% Turkish.  Bayezid Is mother was Greek, so he was 25% Turkish.   The fifth sultans mother was Oghuz, so he was 62.5% Turkish. Continuing in the fashion, Suleiman the Magnificent, the tenth sultan, had about 24% Turkish blood.   According to our calculations, by the time we get to the 36th and final sultan of the Ottoman Empire, Mehmed VI (r. 1918 - 1922), the Oghuz blood was so diluted that he was only about 0.195% Turkic. All of those generations of mothers from Greece, Poland, Venice, Russia, France, and beyond really drowned out the sultans genetic roots on the steppes of Central Asia. List of Ottoman Sultans and their Mothers Ethnicities Osman I, TurkishOrhan, TurkishMurad I, GreekBayezid I, GreekMehmed I, TurkishMurad II, TurkishMehmed II, TurkishBayezid II, TurkishSelim I, GreekSuleiman I, GreekSelim II, PolishMurad III, Italian (Venetian)Mehmed III, Italian (Venetian)Ahmed I, GreekMustafa I, AbkhazianOsman II, Greek or Serbian (?)Murad IV, GreekIbrahim, GreekMehmed IV, UkrainianSuleiman II, SerbianAhmed II, PolishMustafa II, GreekAhmed III, GreekMahmud I, GreekOsman III, SerbianMustafa III, FrenchAbdulhamid I, HungarianSelim III, GeorgianMustafa IV, BulgarianMahmud II, GeorgianAbdulmecid I, Georgian or Russian (?)Abdulaziz I, RomanianMurad V, GeorgianAbdulhamid II, Armenian or Russian (?)Mehmed V, AlbanianMehmed VI, Georgian